Clinical Studies

After years of scientific research and clinical studies, which were designed, conducted, and advised by some of the world’s most accomplished sleep researchers, Ebb Therapeutics brings forth Ebb® with PrecisionCoolTM Technology, one of the latest, drug-free innovations in the pursuit of solving sleeplessness.

1. Evidence of racing thoughts in adults with sleeplessness (Journal of Clinical Sleep Medicine 2006;2: 316-322)

Ebb founder Dr. Eric Nofzinger’s clinical study published in 2006 demonstrated the frontal cortex works overtime in individuals with sleeplessness, creating racing thoughts and making it difficult for the brain to drift naturally into sleep and stay asleep across the night. This racing mind effect is demonstrated via increased metabolic activity in the frontal cortex of the brain.

2. Precise, constant therapeutic cooling of the forehead reduces racing thoughts in adults with sleeplessness (SLEEP 2009; Abstract 0881)

Dr. Nofzinger’s clinical study published in 2009 demonstrated that applying precise, constant cooling to the forehead of individuals with sleeplessness led to significant reductions in metabolic activity in the frontal cortex of the brain. These reductions in activity allowed participants to fall asleep faster and achieve better sleep across the night.

3. Ebb® with PrecisionCoolTM technology was demonstrated in clinical studies to help people with sleeplessness to fall asleep and enter deeper, more restorative sleep faster (SLEEP 2017; Abstract 0381)

Three additional independent clinical studies were conducted in seven prestigious sleep centers across the U.S. on more than 230 patients. Over 3,800 research nights, Ebb demonstrated the safety and effectiveness of its precise cooling. In the primary randomized controlled trial, participants used Ebb for multiple nights in a sleep lab and were assessed by Polysomnographic recordings analyzed by sleep clinicians. The innovation’s precise cooling produced improvements in the ability for participants to fall asleep and enter deeper, more restorative sleep faster. Participants experienced no significant side effects.

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